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Three Factors in Cleanroom Cleaning
Three Factors in Cleanroom Cleaning1, the inner surface of the clean room and its internal equipmentThe principle is that the selection of materials is important, and daily cleaning and disinfection are even more important. To comply with GMP and achieve cleanliness specifications, all surfaces of the clean room should be smooth and impermeable, and not produce pollution, i.e., do not produce dust, or falling debris, corrosion-resistant, easy to clean, otherwise, it will provide a place for microbes to multiply, and the surfaces should be strong and durable, and can not be cracked, broken, or dented. There is a wide range of materials to choose from, from expensive Dagarde paneling to glass etc. The best and most aesthetically pleasing option is glass. Regular cleaning and disinfection are carried out by the requirements of cleanrooms at all levels, and the frequency can be several times a day, every day, every few days, once a week, etc. for cleaning and disinfection after each operation. It is recommended that the operating table should be cleaned and disinfected after each operation, the floor should be disinfected every day, the wall should be disinfected every week, and the space should be disinfected every month, according to the level of the clean room and the set standard specification to carry out strict cleaning and disinfecting operation, and make records. 2， Clean room air control In general, to choose the right clean room design, regular maintenance, and good daily monitoring. Special attention should be paid to the pharmaceutical clean room plankton monitoring, the space of the planktonic bacteria with the planktonic bacteria sampling instrument to extract a certain volume of air in the space, the airflow through the filling of a specific culture medium contact dish, contact dish will capture microorganisms, and then put the dish into the incubator culture to count the number of colonies, calculated the number of microorganisms in the space. The microorganisms in the laminar flow layer also need to be detected, with the corresponding laminar flow layer plankton sampler, the working principle is similar to space sampling, only the sampling point should be put into the laminar flow layer. If the aseptic room needs to use compressed gas, and also needs microbiological testing of compressed air, with the corresponding compressed air detector, you need to first adjust the air pressure of compressed gas to the appropriate range, to prevent microorganisms and the culture medium is destroyed. 3， Requirements of personnel in the clean room The personnel working in the clean room should receive regular training in pollution control theory. They enter and exit the cleanroom through airlocks, air showers, and/or changing rooms, and they must wear specially designed clothing that wraps around the skin and body to naturally occurring contaminants. Depending on the classification or function of the cleanroom, staff attire may be as simple as lab coats and hoods for simple protection or as full body protection that completely encases without exposing any skin. Clean clothing is used to prevent the release of particles and or microorganisms from the wearer's body and contamination of the environment. The suit itself must not release particles or fibers to prevent contamination of the environment. This type of personnel contamination can degrade product performance in the semiconductor and pharmaceutical industries, and it can lead to cross-contamination between medical staff and patients in the healthcare industry, for example. |
