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Application of high-efficiency filters in the pharmaceutical industry
Application of high-efficiency filters in the pharmaceutical industryThe health and safety requirements of the pharmaceutical industry present a serious challenge to filtration technology - dust can lead to contamination, health damage, and the risk of explosions, so the use of high-efficiency filters is essential. The problem is that filters usually require a lot of maintenance to deal with component wear and tear, which means considerable time and money.Highly airtight and safe design The benefits of using long-life filter elements go beyond saving running costs, enabling uninterrupted operation, and ensuring a healthy and safe working environment. In the past, it was thought that dust collection and disposal could be carried out in open systems. Nowadays, more and more APIs require a comprehensive and measurable sealed process. As a result, changing filter cartridges has become less easy. This is not only happening in the pharmaceutical industry but also in many other industries. The background is that by mid-2018, the requirements of the REACH (European Regulation on the Registration, Evaluation, Authorisation, and Control of Chemicals) directive must be implemented. For several reasons, such as the nature of the dust or adjustments to the tableting process, solid preparations generate a large amount of dust-containing gas streams during purification, which must be safely isolated from the process gases. Cleaning and replacement of the filter cartridges is a key point that requires close attention in a well-thought-out and detailed sealing solution. Bag inlet/outlet and sealing technology is commonly used to replace filter elements under closed conditions. Replacing a filter element requires two workers and approximately one hour. In this case, the long-life design of TRM filters minimizes the cumulative risk of improper handling. As the time between filter changes increases, the health risk of the entire process decreases. Explosion-proof filter element design: TRM filter elements with a durable design exceed structural explosion-proof and filter rating requirements. Our goal: zero system leakage. To achieve this goal, a dust removal filtration system is essential. Generally speaking, the dirty air side air chamber located before the first filtration stage has the potential to explode, depending on the nature of the dust and the organic solvents mixed with it. Based on state-of-the-art technology, dust filtration systems allow the pressure generated by an explosion to be safely vented to the clean air side of the chamber. In TRM filtration systems, the primary filter blocks the flame generated by the explosion and prevents the provision of an ignition source for organic solvents passing through the primary filter, thus eliminating the possibility of an explosion of organic solvent residues after the mixed dust has passed through the primary filter. The electrostatic discharge design of the cartridge element prevents electrostatic build-up on the filter. Even the slightest electrostatic charge deposited on the filter membrane is conducted in time to prevent electrostatic sparking. In contrast, mixed dusts have a minimum ignition energy (MIE) of <1 MJ. The electrostatic discharge design prevents any possibility of electrostatic sparking of the filter membrane. |
